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Article

Comparative genomic analysis of primary tumors and metastases in breast cancer.

Oncotarget - 10 May 2016

Bertucci François, Finetti Pascal, Guille Arnaud, Adélaïde José, Garnier Séverine, Carbuccia Nadine, Monneur Audrey, Charafe-Jauffret Emmanuelle, Goncalves Anthony, Viens Patrice, Birnbaum Daniel, Chaffanet Max

Abstract excerpt

Personalized medicine uses genomic information for selecting therapy in patients with metastatic cancer. An issue is the optimal tissue source (primary tumor or metastasis) for testing. We compared the DNA copy number and mutational profiles of primary breast cancers and paired metastases from 23 patients using whole-genome array-comparative genomic hybridization and next-generation sequencing of 365...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27028851
DOI: 10.18632/oncotarget.8349
PMCID: PMC5053643

Genes

ERBB2
AKT1
CCND1
FGFR1
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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