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Article

Impact of clinical targeted sequencing on endocrine responsiveness in estrogen receptor-positive, HER2-negative metastatic breast cancer.

Scientific reports - 14 Apr 2021

Hagio Kanako, Amano Toraji, Hayashi Hideyuki, Takeshita Takashi, Oshino Tomohiro, Kikuchi Junko, Ohhara Yoshihito, Yabe Ichiro, Kinoshita Ichiro, Nishihara Hiroshi, Yamashita Hiroko

Abstract excerpt

Clinical targeted sequencing allows for the selection of patients expected to have a better treatment response, and reveals mechanisms of resistance to molecular targeted therapies based on actionable gene mutations. We underwent comprehensive genomic testing with either our original in-house CLHURC system or with OncoPrime. Samples from 24 patients with estrogen receptor-positive, human epidermal growth factor...

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Identifiers

PMID: 33854152
DOI: 10.1038/s41598-021-87645-6
PMCID: PMC8047009

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