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Article

Mitochondrial aldehyde dehydrogenase 2 deficiency aggravates energy metabolism disturbance and diastolic dysfunction in diabetic mice.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2016

Wang Cong, Fan Fan, Cao Quan, Shen Cheng, Zhu Hong, Wang Peng, Zhao Xiaona, Sun Xiaolei, Dong Zhen, Ma Xin, Liu Xiangwei, Han Shasha, Wu Chaoneng, Zou Yunzeng, Hu Kai, Ge Junbo, Sun Aijun

Abstract excerpt

Diabetes causes energy metabolism disturbance and may lead to cardiac dysfunction. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) protects cardiac function from myocardial damage. Therefore, understanding of its roles in diabetic heart is critical for developing new therapeutics targeting ALDH2 and mitochondrial function for diabetic hearts. This study investigated the impact of ALDH2 deficiency on diastolic...

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Share to Aldehyde Dehydrogenase, Mitochondrial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to AMP-Activated Protein Kinases

Share to Diabetes Mellitus, Experimental

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Source

Identifiers

PMID: 27488451
DOI: 10.1007/s00109-016-1449-5

Genes

ALDH2

Provenance

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