Article
Disruption of polycystin-1 cleavage leads to cardiac metabolic rewiring in mice.
Biochimica et biophysica acta. Molecular basis of disease - 1 Jun 2022
Amaral Andressa G, da Silva Camille C C, Serna Julian D C, Honorato-Sampaio Kinulpe, Freitas Jéssica A, Duarte-Neto Amaro N, Bloise Antonio C, Cassina Laura, Yoshinaga Marcos Y, Chaves-Filho Adriano B, Qian Feng, Miyamoto Sayuri, Boletta Alessandra, Bordin Silvana, Kowaltowski Alicia J, Onuchic Luiz F
Abstract excerpt
Cardiovascular manifestations account for marked morbi-mortality in autosomal dominant polycystic kidney disease (ADPKD). Pkd1- and Pkd2-deficient mice develop cardiac dysfunction, however the underlying mechanisms remain largely unclear. It is unknown whether impairment of polycystin-1 cleavage at the G-protein-coupled receptor proteolysis site, a significant ADPKD mutational mechanism, is involved in this...
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