Article
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.
Circulation - 10 Mar 2009
Boudina Sihem, Bugger Heiko, Sena Sandra, O'Neill Brian T, Zaha Vlad G, Ilkun Olesya, Wright Jordan J, Mazumder Pradip K, Palfreyman Eric, Tidwell Timothy J, Theobald Heather, Khalimonchuk Oleh, Wayment Benjamin, Sheng Xiaoming, Rodnick Kenneth J, Centini Ryan, Chen Dong, Litwin Sheldon E, Weimer Bart E, Abel E Dale
Abstract excerpt
BACKGROUND: Diabetes-associated cardiac dysfunction is associated with mitochondrial dysfunction and oxidative stress, which may contribute to left ventricular dysfunction. The contribution of altered myocardial insulin action, independent of associated changes in systemic metabolism, is incompletely understood. The present study tested the hypothesis that perinatal loss of insulin signaling in the heart impairs...
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