Article

Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with HFpEF cardiometabolic phenotype

2025-04-16

Abstract excerpt

<h4>Background</h4> Heart failure with preserved ejection fraction (HFpEF) poses a significant global health challenge, disproportionately affecting women. Diabetic women with HFpEF represent a high-risk subgroup, particularly after experiencing ST-segment elevation myocardial infarction (STEMI), exhibiting increased mortality compared to men. While prolonged door-to-balloon (DTB) times, reflecting delayed reperfu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8097cf56-cdcb-5d1b-9ad2-15fc2d7c4a34
DOI: 10.1101/2025.04.14.25325801

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with HFpEF cardiometabolic phenotypeDOI 10.1101/2025.04.14.25325801Read

Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with HFpEF cardiometabolic phenotype.Semantic proximity Read

Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse modelSemantic proximity Read

How Diabetes and Heart Failure Modulate Each Other and Condition Management.Semantic proximity Read

Multi-omics reveals lipid metabolism, mitochondrial and extracellular matrix dysregulation of diabetic cardiomyopathy in the human heartSemantic proximity Read

Molecular Dysfunction and Phenotypic Derangement in Diabetic CardiomyopathySemantic proximity Read

Multiomics-based assessment of 2D and 3D human iPSC-cardiomyocyte models of insulin resistance demonstrate metabolic and contractile dysfunction that recapitulates diabetic cardiomyopathySemantic proximity Read

Left ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathySemantic proximity Read

Integrative Analysis of Left Ventricle and Epicardial Adipose Tissue Identifies SDHA and OGDH as Candidate Targets for Ischemic Heart DiseaseSemantic proximity Read

Transcriptomic analysis of the cardiac left ventricle in a rodent model of diabetic cardiomyopathy: molecular snapshot of a severe myocardial diseaseSemantic proximity Read

Novel Insights Into the Pathogenesis of Diabetic Cardiomyopathy and Pharmacological StrategiesSemantic proximity Read

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetesSemantic proximity Read

Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial.Semantic proximity Read