Article
Detection of Mutations in Barrett's Esophagus Before Progression to High-Grade Dysplasia or Adenocarcinoma.
Gastroenterology - 1 Jul 2018
Stachler Matthew D, Camarda Nicholas D, Deitrick Christopher, Kim Anthony, Agoston Agoston T, Odze Robert D, Hornick Jason L, Nag Anwesha, Thorner Aaron R, Ducar Matthew, Noffsinger Amy, Lash Richard H, Redston Mark, Carter Scott L, Davison Jon M, Bass Adam J
Abstract excerpt
BACKGROUND & AIMS: Barrett's esophagus (BE) is the greatest risk factor for esophageal adenocarcinoma (EAC), but only a small proportion of patients with BE develop cancer. Biomarkers might be able to identify patients at highest risk of progression. We investigated genomic differences in surveillance biopsies collected from patients whose BE subsequently progressed compared to patients whose disease did not...
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