Article
The Presence of Genetic Mutations at Key Loci Predicts Progression to Esophageal Adenocarcinoma in Barrett's Esophagus.
The American journal of gastroenterology - 1 Jun 2015
Eluri Swathi, Brugge William R, Daglilar Ebubekir S, Jackson Sara A, Styn Mindi A, Callenberg Keith M, Welch Derek C, Barr Todd M, Duits Lucas C, Bergman Jacques J, Shaheen Nicholas J
Abstract excerpt
OBJECTIVES: Risk stratification in Barrett's esophagus (BE) is challenging. We evaluated the ability of a panel of genetic markers to predict progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). METHODS: In this case-control study, we assessed a measure of genetic instability, the mutational load (ML), in predicting progression to HGD or EAC. Cases had nondysplastic BE or low-grade...
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