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Article

Aberrant TP53 detected by combining immunohistochemistry and DNA-FISH improves Barrett's esophagus progression prediction: a prospective follow-up study.

Genes, chromosomes & cancer - 1 Feb 2015

Davelaar Akueni L, Calpe Silvia, Lau Liana, Timmer Margriet R, Visser Mike, Ten Kate Fiebo J, Parikh Kaushal B, Meijer Sybren L, Bergman Jacques J, Fockens Paul, Krishnadath Kausilia K

Abstract excerpt

Barrett's esophagus (BE) goes through a sequence of low grade dysplasia (LGD) and high grade dysplasia (HGD) to esophageal adenocarcinoma (EAC). The current gold standard for BE outcome prediction, histopathological staging, can be unreliable. TP53 abnormalities may serve as prognostic biomarkers. TP53 protein accumulation detected by immunohistochemistry (IHC) indirectly assesses TP53 mutations. DNA fluorescent...

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PMID: 25284618
DOI: 10.1002/gcc.22220

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HGD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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