Germline CDH1 mutations are a significant contributor to the high frequency of early-onset diffuse gastric cancer cases in New Zealand Māori.

doi:10.1007/s10689-018-0080-8

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Article

Germline CDH1 mutations are a significant contributor to the high frequency of early-onset diffuse gastric cancer cases in New Zealand Māori.

Familial cancer - 1 Jan 2019

Hakkaart Christopher, Ellison-Loschmann Lis, Day Robert, Sporle Andrew, Koea Jonathan, Harawira Pauline, Cheng Soo, Gray Michelle, Whaanga Tracey, Pearce Neil, Guilford Parry

Abstract excerpt

New Zealand Māori have a considerably higher incidence of gastric cancer compared to non-Māori, and are one of the few populations worldwide with a higher prevalence of diffuse-type disease. Pathogenic germline CDH1 mutations are causative of hereditary diffuse gastric cancer, a cancer predisposition syndrome primarily characterised by an extreme lifetime risk of developing diffuse gastric cancer. Pathogenic CDH1...

Topics

Adolescent
Adult
Age of Onset
Aged
Aged, 80 and over
Antigens, CD
Cadherins
DNA Mutational Analysis
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Testing

Germ-Line Mutation

High-Throughput Nucleotide Sequencing

Humans

Incidence

Male

Middle Aged

New Zealand

Source

Open in PubMed Open full text

Identifiers

PMID: 29589180
DOI: 10.1007/s10689-018-0080-8
PMCID: PMC6323075

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29589180-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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