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Article

Germline CDH1 mutations are a significant contributor to the high frequency of early-onset diffuse gastric cancer cases in New Zealand Māori.

Familial cancer - 1 Jan 2019

Hakkaart Christopher, Ellison-Loschmann Lis, Day Robert, Sporle Andrew, Koea Jonathan, Harawira Pauline, Cheng Soo, Gray Michelle, Whaanga Tracey, Pearce Neil, Guilford Parry

Abstract excerpt

New Zealand Māori have a considerably higher incidence of gastric cancer compared to non-Māori, and are one of the few populations worldwide with a higher prevalence of diffuse-type disease. Pathogenic germline CDH1 mutations are causative of hereditary diffuse gastric cancer, a cancer predisposition syndrome primarily characterised by an extreme lifetime risk of developing diffuse gastric cancer. Pathogenic CDH1...

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Source

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Identifiers

PMID: 29589180
DOI: 10.1007/s10689-018-0080-8
PMCID: PMC6323075

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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