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Article

Germline variants and phenotypic spectrum in a Canadian cohort of individuals with diffuse gastric cancer.

Current oncology (Toronto, Ont.) - 1 Apr 2020

Aronson M, Swallow C, Govindarajan A, Semotiuk K, Cohen Z, Kaurah P, Velsher L, Ambus I, Buckley K, Forster-Gibson C, Meschino W S, Blumenthal A, Kim R H, Brar S

Abstract excerpt

Background: CDH1 pathogenic variants (pvs) cause most cases of inherited diffuse gastric cancer (dgc), but have low detection rates and vary geographically. In the present study, we examined hereditary causes of dgc in patients in Ontario. Methods: CDH1 testing through single-site or multi-gene panels was conducted for patients with dgc meeting the 2015 International Gastric Cancer Linkage Consortium (igclc)...

Topics

Aged
Canada
Cohort Studies
Germ-Line Mutation
Humans
Middle Aged
Phenotype
Stomach Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32489267
DOI: 10.3747/co.27.5663
PMCID: PMC7253747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-32489267-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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