Article
CDH1 Germline Variants in a Tunisian Cohort with Hereditary Diffuse Gastric Carcinoma.
Genes - 23 Feb 2022
Ben Aissa-Haj Jihenne, Kabbage Maria, Othmen Houcemeddine, Saulnier Patrick, Kettiti Haifa Tounsi, Jaballah-Gabteni Amira, Ferah Azer, Medhioub Mouna, Khsiba Amal, Mahmoudi Moufida, Maaloul Afifa, Ben Nasr Sonia, Chelbi Emna, Abdelhak Sonia, Boubaker M Samir, Azzouz Mohamed Mousaddak, Rouleau Etienne
Abstract excerpt
Mutational screening of the CDH1 gene is a standard treatment for patients who fulfill Hereditary Diffuse Gastric Cancer (HDGC) testing criteria. In this framework, the classification of variants found in this gene is a crucial step for the clinical management of patients at high risk for HDGC. The aim of our study was to identify CDH1 as well as CTNNA1 mutational profiles predisposing to HDGC in Tunisia....
Topics
- Adenocarcinoma
- Antigens, CD
- Cadherins
- Genetic Predisposition to Disease
- Germ Cells
- Germ-Line Mutation
- Humans
- Pedigree
- Stomach Neoplasms