Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hereditary Diffuse Gastric Cancer Syndrome and the Role of CDH1: A Review.

JAMA surgery - 1 Apr 2021

Gamble Lauren A, Heller Theo, Davis Jeremy L

Abstract excerpt

Importance: Inherited variants in the tumor suppressor gene CDH1 are associated with an increased risk of gastric and breast cancers. This review aims to address the most current topics in management of the hereditary diffuse gastric cancer syndrome attributed to CDH1. Observations: Consensus management guidelines have broadened genetic testing criteria for CDH1. Prophylactic total gastrectomy is recommended for...

Topics

Antigens, CD
Cadherins
Genetic Predisposition to Disease
Humans
Neoplastic Syndromes, Hereditary
Stomach Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33404644
DOI: 10.1001/jamasurg.2020.6155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-33404644-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hereditary Diffuse Gastric Cancer Syndrome and the Role of CDH1: A Review.PMID 33404644Read ↗

CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and Histological Alterations and Implications for Diagnosis And TreatmentSemantic proximity Read ↗

Therapeutic and prophylactic gastrectomy in a family with hereditary diffuse gastric cancer secondary to a CDH1 mutation: a case series.Semantic proximity Read ↗

Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline <i>CDH1</i> mutation carriersSemantic proximity Read ↗

Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future researchSemantic proximity Read ↗

Hereditary diffuse gastric cancer: implications of genetic testing for screening and prophylactic surgery.Semantic proximity Read ↗

Overview on new progress of hereditary diffuse gastric cancer with CDH1 variants.Semantic proximity Read ↗

Hereditary diffuse gastric cancer: What the clinician should knowSemantic proximity Read ↗

Points to consider regarding prophylactic total gastrectomy in germline CDH1 variant carriers.Semantic proximity Read ↗

CDH1 and hereditary diffuse gastric cancer: a narrative review.Semantic proximity Read ↗

Hereditary Gastric Cancer Syndromes.Semantic proximity Read ↗

Current advances in understanding the molecular profile of hereditary diffuse gastric cancer and its clinical implications.Semantic proximity Read ↗

Surveillance and Surgical Considerations in Hereditary Diffuse Gastric Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.