A PRDX1-p38α heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas.

doi:10.1002/ijc.31404

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Article

A PRDX1-p38α heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas.

International journal of cancer - 1 Sept 2018

Wirthschaft Peter, Bode Julia, Simon Anika E M, Hoffmann Elisa, van Laack Rebecca, Krüwel Thomas, Dietrich Fabio, Bucher Delia, Hahn Artur, Sahm Felix, Breckwoldt Michael O, Kurz Felix T, Hielscher Thomas, Fischer Bernd, Dross Nicolas, Ruiz de Almodovar Carmen, von Deimling Andreas, Herold-Mende Christel, Plass Christoph, Boulant Steeve, Wiestler Benedikt, Reifenberger Guido, Lichter Peter, Wick Wolfgang, Tews Björn

Abstract excerpt

The Peroxiredoxin 1 (PRDX1) gene maps to chromosome arm 1p and is hemizygously deleted and epigenetically silenced in isocitrate dehydrogenase 1 or 2 (IDH)-mutant and 1p/19q-codeleted oligodendroglial tumors. In contrast, IDH-wildtype astrocytic gliomas including glioblastomas mostly lack epigenetic silencing and express PRDX1 protein. In our study, we investigated how PRDX1 contributes to the infiltrative growth...

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Identifiers

PMID: 29582423
DOI: 10.1002/ijc.31404

Genes

PRDX1
HGF
MET
MAPK14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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