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Article

Actin, connexin-43 and GAP-43 expression in gliomas: real-world associations with IDH status, tumor burden and survival.

Journal of neuro-oncology - 8 Aug 2026

Krigers Aleksandrs, Demetz Matthias, Bergmeister Lisa, Moser Patrizia, Woehrer Adelheid, Thomé Claudius, Freyschlag Christian F

Abstract excerpt

BACKGROUND: Connexin-43 (Cx43), GAP-43 and actin are involved in cellular communication and cytoskeletal dynamics in gliomas, yet their clinical relevance remains largely unclear. We investigated their expression and association with survival and tumor characteristics in IDH-mutant and IDH-wildtype gliomas. METHODS: 134 adult patients operated for newly diagnosed gliomas WHO grades 2-4 in our center were...

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PMID: 42570146
DOI: 10.1007/s11060-026-05745-7
PMCID: PMC13452833

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