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Article

LOX expression and functional analysis in astrocytomas and impact of IDH1 mutation.

PloS one - 1 Jan 2015

da Silva Roseli, Uno Miyuki, Marie Suely K Nagahashi, Oba-Shinjo Sueli M

Abstract excerpt

Lysyl oxidase (LOX) is involved in vital biological processes such as cell motility, cell signaling and gene regulation. Deregulation of this protein can contribute to tumor formation and progression. Although it is known that LOX is involved in invasion, proliferation and tumor migration in other types of tumors, studies of LOX in astrocytomas of different grades are scarce. The purpose of our study was to...

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Share to Astrocytoma
Share to Cell Movement
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Isocitrate Dehydrogenase

Share to Neoplasm Invasiveness

Share to Neovascularization, Pathologic

Share to Scavenger Receptors, Class E

Source

Open in PubMed Open full text

Identifiers

PMID: 25790191
DOI: 10.1371/journal.pone.0119781
PMCID: PMC4366168

Genes

LOX
IDH1
BMP1

Provenance

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