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Article

The advanced development of Cx43 and GAP-43 mediated intercellular networking in IDH1 wildtype diffuse and anaplastic gliomas with lower mitotic rate.

Journal of cancer research and clinical oncology - 1 Oct 2021

Krigers Aleksandrs, Moser Patrizia, Fritsch Helga, Demetz Matthias, Brawanski Konstantin, Thomé Claudius, Freyschlag Christian F

Abstract excerpt

PURPOSE: The biologic behavior and the therapeutic resistance of diffuse and anaplastic gliomas varies greatly. This may be explained by differences in cell-to-cell communication, determined by the Cx43-associated junctional activity and the microtubules-defined network, in which GAP-43 is the dominant structural component. We assessed the expression of these crucial communication proteins in samples of patients...

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Identifiers

PMID: 34173871
DOI: 10.1007/s00432-021-03711-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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