Article
OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant.
Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2018
Taylor Clinton A, An Sung-Wan, Kankanamalage Sachith Gallolu, Stippec Steve, Earnest Svetlana, Trivedi Ashesh T, Yang Jonathan Zijiang, Mirzaei Hamid, Huang Chou-Long, Cobb Melanie H
Abstract excerpt
The with-no-lysine (K) (WNK) signaling pathway to STE20/SPS1-related proline- and alanine-rich kinase (SPAK) and oxidative stress-responsive 1 (OSR1) kinase is an important mediator of cell volume and ion transport. SPAK and OSR1 associate with upstream kinases WNK 1-4, substrates, and other proteins through their C-terminal domains which interact with linear R-F-x-V/I sequence motifs. In this study we find that...
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