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Article

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.

The Biochemical journal - 1 Jan 2012

Thastrup Jacob O, Rafiqi Fatema H, Vitari Alberto C, Pozo-Guisado Eulalia, Deak Maria, Mehellou Youcef, Alessi Dario R

Abstract excerpt

Mutations in the WNK [with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has been on WNK1, which is activated in response to osmotic stress by phosphorylation of its T-loop residue (Ser382). WNK isoforms phosphorylate and activate the related SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22032326
DOI: 10.1042/BJ20111879
PMCID: PMC3242505

Genes

OSR1
WNK1
WNK3
WNK2
WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.PMID 22032326Read ↗

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.Semantic proximity Read ↗

Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.Semantic proximity Read ↗

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.Semantic proximity Read ↗

SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.Semantic proximity Read ↗

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.Semantic proximity Read ↗

WNKs: protein kinases with a unique kinase domain.Semantic proximity Read ↗

Characterization of the kinase activity of a WNK4 protein complex.Semantic proximity Read ↗

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.Semantic proximity Read ↗

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.Semantic proximity Read ↗

OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant.Semantic proximity Read ↗

SPAK and OSR1 Sensitive Kir2.1 K+ Channels.Semantic proximity Read ↗

Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase.Semantic proximity Read ↗

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