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Article

SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.

PloS one - 1 Jan 2013

Chu Pei-Yi, Cheng Chih-Jen, Wu Yi-Chang, Fang Yu-Wei, Chau Tom, Uchida Shinichi, Sasaki Sei, Yang Sung-Sen, Lin Shih-Hua

Abstract excerpt

Stimulation of the OSR1 (Oxidative stress-responsive kinase-1)/SPAK [STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase]-NCC (Na(+)-Cl(-) cotransporter) signaling cascade plays an important role in the WNK [With-No-Lysine (K)] kinase 4 D561A knock-in mouse model of pseudohypoaldosteronism type II (PHA II) characterized by salt-sensitive hypertension and hyperkalemia. The aim of this study was to...

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Identifiers

PMID: 24039833
DOI: 10.1371/journal.pone.0072969
PMCID: PMC3770638

Genes

OSR1
WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.PMID 24039833Read ↗

WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.Semantic proximity Read ↗

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.Semantic proximity Read ↗

Generation and analysis of pseudohypoaldosteronism type II knock-in mice caused by a nonsense KLHL3 mutation in the Kelch domain.Semantic proximity Read ↗

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.Semantic proximity Read ↗

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.Semantic proximity Read ↗

Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.Semantic proximity Read ↗

WNK Kinases, Renal Ion Transport and HypertensionSemantic proximity Read ↗

Mechanisms of type I and type II pseudohypoaldosteronism.Semantic proximity Read ↗

Pathogenesis of pseudohypoaldosteronism type 2 by WNK1 mutations.Semantic proximity Read ↗

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.Semantic proximity Read ↗

Characterization of the kinase activity of a WNK4 protein complex.Semantic proximity Read ↗

WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.Semantic proximity Read ↗

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