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Article

In silico analysis and experimental verification of OSR1 kinase - Peptide interaction.

Journal of structural biology - 1 Jul 2014

Austin Thomas M, Nannemann David P, Deluca Samuel L, Meiler Jens, Delpire Eric

Abstract excerpt

The oxidative-stress-responsive kinase 1 (OSR1) and the STE20/SPS1-related proline/alanine-rich kinase (SPAK) are key enzymes in a signaling cascade regulating the activity of Na(+)-K(+)-2Cl(-) cotransporters (NKCC1-2) and Na(+)-Cl(-) cotransporter (NCC). Both kinases have a conserved carboxyl-terminal (CCT) domain, which recognizes a unique peptide motif present in OSR1- and SPAK-activating kinases...

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Source

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Identifiers

PMID: 24821279
DOI: 10.1016/j.jsb.2014.05.001
PMCID: PMC4082687

Genes

OSR1
WNK4
WNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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In silico analysis and experimental verification of OSR1 kinase - Peptide interaction.PMID 24821279Read ↗

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