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Article

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

The Biochemical journal - 1 Jul 2006

Vitari Alberto C, Thastrup Jacob, Rafiqi Fatema H, Deak Maria, Morrice Nick A, Karlsson Håkan K R, Alessi Dario R

Abstract excerpt

The SPAK (STE20/SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase-1) kinases interact and phosphorylate NKCC1 (Na+-K+-2Cl- co-transporter-1), leading to its activation. Recent studies indicated that SPAK and OSR1 are phosphorylated and activated by the WNK1 [with no K (lysine) protein kinase-1] and WNK4, genes mutated in humans affected by Gordon's hypertension syndrome. In...

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Source

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Identifiers

PMID: 16669787
DOI: 10.1042/BJ20060220
PMCID: PMC1479760

Genes

OSR1
WNK1
WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.PMID 16669787Read ↗

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.Semantic proximity Read ↗

In silico analysis and experimental verification of OSR1 kinase - Peptide interaction.Semantic proximity Read ↗

Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase.Semantic proximity Read ↗

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.Semantic proximity Read ↗

SPAK and OSR1 Sensitive Kir2.1 K+ Channels.Semantic proximity Read ↗

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.Semantic proximity Read ↗

OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant.Semantic proximity Read ↗

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Predictive and Experimental Motif Interaction Analysis Identifies Functions of the WNK-OSR1/SPAK PathwaySemantic proximity Read ↗

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