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Article

Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.

American journal of physiology. Renal physiology - 15 Feb 2015

Roy Ankita, Goodman Joshua H, Begum Gulnaz, Donnelly Bridget F, Pittman Gabrielle, Weinman Edward J, Sun Dandan, Subramanya Arohan R

Abstract excerpt

Sodium-coupled SLC12 cation chloride cotransporters play important roles in cell volume and chloride homeostasis, epithelial fluid secretion, and renal tubular salt reabsorption. These cotransporters are phosphorylated and activated indirectly by With-No-Lysine (WNK) kinases through their downstream effector kinases, Ste20- and SPS1-related proline alanine-rich kinase (SPAK) and oxidative stress-responsive kinase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25477473
DOI: 10.1152/ajprenal.00612.2014
PMCID: PMC4329490

Genes

WNK1
OSR1
WNK4
KLHL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.PMID 25477473Read ↗

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