Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SPAK and OSR1 Sensitive Kir2.1 K+ Channels.

Neuro-Signals - 1 Jan 2015

Fezai Myriam, Ahmed Musaab, Hosseinzadeh Zohreh, Elvira Bernat, Lang Florian

Abstract excerpt

BACKGROUND/AIMS: Kir2.1 (KCNJ2) channels are expressed in neurons, skeletal muscle and cardiac tissue and maintain the resting membrane potential. The activity of those channels is regulated by diverse signalling molecules. The present study explored whether Kir2.1 channels are sensitive to the transporter and channels regulating kinases SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biophysical Phenomena
Share to Brefeldin A
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to Microinjections

Share to Potassium Channels, Inwardly Rectifying

Share to Protein Synthesis Inhibitors

Share to Xenopus laevis

Source

Identifiers

PMID: 26673921
DOI: 10.1159/000442601

Genes

OSR1
KCNJ2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SPAK and OSR1 Sensitive Kir2.1 K+ Channels.PMID 26673921Read ↗

Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1.Semantic proximity Read ↗

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.Semantic proximity Read ↗

OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant.Semantic proximity Read ↗

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.Semantic proximity Read ↗

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.Semantic proximity Read ↗

Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and DiseaseSemantic proximity Read ↗

Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase.Semantic proximity Read ↗

SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.Semantic proximity Read ↗

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.Semantic proximity Read ↗

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.Semantic proximity Read ↗

The sodium-activated potassium channel is encoded by a member of the Slo gene family.Semantic proximity Read ↗

PIP₂ modulation of Slick and Slack K⁺ channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.