Article

Predictive and Experimental Motif Interaction Analysis Identifies Functions of the WNK-OSR1/SPAK Pathway

2024-06-27

Abstract excerpt

<h4>ABSTRACT</h4> The WNK-OSR1/SPAK protein kinase signaling pathway regulates ion homeostasis and cell volume, but its other functions are poorly understood. To uncover undefined signaling functions of the pathway we analyzed the binding specificity of the conserved C-terminal (CCT) domains of OSR1 and SPAK to find all possible interaction motifs in human proteins. These kinases bind the core consensus sequences...

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Literature Corpus work: 4400db3c-a61e-5eb5-bc05-1de9d02c9105
DOI: 10.1101/2024.06.26.600905

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