Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion.

doi:10.1371/journal.pone.0194661

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Article

Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion.

PloS one - 1 Jan 2018

Dresselhaus Erica, Duerr James M, Vincent Fabien, Sylvain Emily K, Beyna Mercedes, Lanyon Lorraine F, LaChapelle Erik, Pettersson Martin, Bales Kelly R, Ramaswamy Gayathri

Abstract excerpt

Despite the important role of apolipoprotein E (apoE) secretion from astrocytes in brain lipid metabolism and the strong association of apoE4, one of the human apoE isoforms, with sporadic and late onset forms of Alzheimer's disease (AD) little is known about the regulation of astrocytic apoE. Utilizing annotated chemical libraries and a phenotypic screening strategy that measured apoE secretion from a human...

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Identifiers

PMID: 29579087
DOI: 10.1371/journal.pone.0194661
PMCID: PMC5868809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.