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Article

Construction of a mutant of Actinoplanes sp. N902-109 that produces a new rapamycin analog.

Chinese journal of natural medicines - 1 Mar 2018

Huang He, Gao Ping, Zhao Qi, Hu Hai-Feng

Abstract excerpt

In the present study, we introduced point mutations into Ac_rapA which encodes a polyketide synthase responsible for rapamycin biosynthesis in Actinoplanes sp. N902-109, in order to construct a mutant with an inactivated enoylreductase (ER) domain, which was able to synthesize a new rapamycin analog. Based on the homologous recombination induced by double-strand breaks in chromosome mediated by endonuclease...

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PMID: 29576057
DOI: 10.1016/S1875-5364(18)30049-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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