Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insights into the metabolic mechanism of rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative metabolomics.

World journal of microbiology & biotechnology - 1 Jun 2017

Geng Huiyan, Liu Huanhuan, Liu Jiao, Wang Cheng, Wen Jianping

Abstract excerpt

Rapamycin is a polyketide with a 31-membered macrolide ring that possesses powerful immunosuppressant activity. In this study, we firstly obtained a mutant, shikimate-resistant Streptomyces hygroscopicus strain UV-II, which displayed about 3.20-fold higher rapamycin production (305.9 mg/L) than the wild-type S. hygroscopicus ATCC29253 (95.5 mg/L). Under optimal conditions, with the addition of 2 g/L shikimic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriological Techniques
Share to Fermentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Immunosuppressive Agents

Share to Metabolic Networks and Pathways

Share to Metabolomics

Share to Sirolimus

Share to Streptomyces

Source

Identifiers

PMID: 28466297
DOI: 10.1007/s11274-017-2266-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights into the metabolic mechanism of rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative metabolomics.PMID 28466297Read ↗

Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus.Semantic proximity Read ↗

Generation of high-yield rapamycin-producing strains through protoplasts-related techniques.Semantic proximity Read ↗

Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.Semantic proximity Read ↗

Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysisSemantic proximity Read ↗

Alligamycin A, an antifungal β-lactone spiroketal macrolide from Streptomyces iranensisSemantic proximity Read ↗

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of genes flanking the polyketide synthaseSemantic proximity Read ↗

A high-throughput method for screening of rapamycin-producing strains of Streptomyces hygroscopicus by cultivation in 96-well microtiter plates.Semantic proximity Read ↗

Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensisSemantic proximity Read ↗

Improvement of microbial strain and fermentation process of rapamycin biosynthesis.Semantic proximity Read ↗

Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP.Semantic proximity Read ↗

Construction of a mutant of Actinoplanes sp. N902-109 that produces a new rapamycin analog.Semantic proximity Read ↗

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.