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Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase

11 May 2021

Abstract excerpt

Engineering polyketide synthases is one of the most promising ways of producing a variety of polyketide derivatives. Exploring the undiscovered chemical space of this medicinally important class of middle molecular weight natural products will aid in the development of improved drugs in the future. In previous work, we established methodology designated 'module editing' to precisely manipulate polyketide synthase...

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PMID: 33976244
DOI: 10.1038/s41598-021-88583-z

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