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Improvement of microbial strain and fermentation process of rapamycin biosynthesis.

Preparative biochemistry & biotechnology - 1 Jan 2013

Baby Rani Polavarapu, Battula Suneel Kumar, Rao A K S Bhujanga, Gunja Madhavi, Narasu Mangamoori Lakshmi

Abstract excerpt

The purpose of this investigation is to enhance the production of the immunosuppressant drug rapamycin by subjecting the strain CBS 773.23 to ultraviolet (UV) and N-methyl-N'-nitro-N-nitroso guanidine (NTG) mutations. Among all the mutants tested, MTCC 5681 (NRC-CM03/SH) obtained by NTG mutagenesis of strain CBS 773.72 showed the highest activity, 210 mg/L. The effect of different factors including medium...

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Identifiers

PMID: 23742086
DOI: 10.1080/10826068.2012.759969

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CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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