Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer

8 Feb 2014

Abstract excerpt

BACKGROUND: Polyoxypeptin A was isolated from a culture broth of Streptomyces sp. MK498-98 F14, which has a potent apoptosis-inducing activity towards human pancreatic carcinoma AsPC-1 cells. Structurally, polyoxypeptin A is composed of a C₁₅ acyl side chain and a nineteen-membered cyclodepsipeptide core that consists of six unusual nonproteinogenic amino acid residues (N-hydroxyvaline, 3-hydroxy-3-methylproline,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological and pharmacological studies of plants
Share to Microbial Natural Products and Biosynthesis
Share to Quinazolinone synthesis and applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24506891
DOI: 10.1186/1471-2180-14-30

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducerPMID 24506891Read ↗

P<scp>OLYKETIDE</scp> P<scp>RODUCTION BY</scp> P<scp>LANT</scp>-A<scp>SSOCIATED</scp> P<scp>SEUDOMONADS</scp>Semantic proximity Read ↗

Isolation of a Novel Cyclic Hexadepsipeptide Pipalamycin from Streptomyces as an Apoptosis-inducing Agent.Semantic proximity Read ↗

p-Aminophenylalanine Involved in the Biosynthesis of Antitumor Dnacin B1 for Quinone Moiety Formation.Semantic proximity Read ↗

Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica.Semantic proximity Read ↗

Bioinformatic and mechanistic analysis of the palmerolide PKS-NRPS biosynthetic pathway from the microbiome of an Antarctic ascidianSemantic proximity Read ↗

Characterization of the biosynthetic gene cluster of the polyene macrolide antibiotic reedsmycins from a marine-derived Streptomyces strainSemantic proximity Read ↗

Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor.Semantic proximity Read ↗

Bacterial Biosynthetic Gene Clusters Encoding the Anti-cancer Haterumalide Class of MoleculesSemantic proximity Read ↗

Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulationSemantic proximity Read ↗

Chloptosin, an Apoptosis-Inducing Dimeric Cyclohexapeptide Produced by StreptomycesSemantic proximity Read ↗

Identification and Proposed Relative and Absolute Configurations of Niphimycins C–E from the Marine-Derived Streptomyces sp. IMB7-145 by Genomic AnalysisSemantic proximity Read ↗

Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin ASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.