Article

Alligamycin A, an unprecedented antifungal β-lactone spiroketal macrolide from <i>Streptomyces iranensis</i>

2024-04-17

Abstract excerpt

Fungal infections pose a great threat to public health and there are limited antifungal medicaments. Streptomyces is an important source of antibiotics, represented by the clinical drug amphotericin B. The rapamycin-producer Streptomyces iranensis harbors an unparalleled Type I polyketide synthase, which codes for a novel antifungal macrolide alligamycin A ( 1 ), the structure of which was confirmed by NMR, MS,...

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Literature Corpus work: 064a1cde-be40-5f0b-bc83-450c585c44fe
DOI: 10.1101/2024.04.17.589928

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