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Article

Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.

Journal of bacteriology - 1 Jul 2007

Kuscer Enej, Coates Nigel, Challis Iain, Gregory Matt, Wilkinson Barrie, Sheridan Rose, Petković Hrvoje

Abstract excerpt

Rapamycin is an important macrocyclic polyketide produced by Streptomyces hygroscopicus and showing immunosuppressive, antifungal, and antitumor activities as well as displaying anti-inflammatory and neuroregenerative properties. The immense pharmacological potential of rapamycin has led to the production of an array of analogues, including through genetic engineering of the rapamycin biosynthetic gene cluster....

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Share to Chromatography, High Pressure Liquid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17468238
DOI: 10.1128/JB.00129-07
PMCID: PMC1913445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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