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Article

Functional Analysis of P450 Monooxygenase SrrO in the Biosynthesis of Butenolide-Type Signaling Molecules in Streptomycesrochei.

Biomolecules - 25 Aug 2020

Teshima Aiko, Hadae Nozomi, Tsuda Naoto, Arakawa Kenji

Abstract excerpt

Streptomyces rochei 7434AN4 produces two structurally unrelated polyketide antibiotics lankacidin and lankamycin, and their biosynthesis is tightly controlled by butenolide-type signaling molecules SRB1 and SRB2. SRBs are synthesized by SRB synthase SrrX, and induce lankacidin and lankamycin production at 40 nM concentration. We here investigated the role of a P450 monooxygenase gene srrO (orf84), which is...

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PMID: 32854353
DOI: 10.3390/biom10091237
PMCID: PMC7564063

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Source receipt: pubmed, retrieved 7 Sept 2026.

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