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Article

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.

Gastroenterology - 1 Apr 2016

Robles Ana I, Traverso Giovanni, Zhang Ming, Roberts Nicholas J, Khan Mohammed A, Joseph Christine, Lauwers Gregory Y, Selaru Florin M, Popoli Maria, Pittman Meredith E, Ke Xiquan, Hruban Ralph H, Meltzer Stephen J, Kinzler Kenneth W, Vogelstein Bert, Harris Curtis C, Papadopoulos Nickolas

Abstract excerpt

BACKGROUND & AIMS: A long duration of inflammatory bowel disease (IBD) increases the risk for colorectal cancer. Mutation analysis of limited numbers of genes has indicated that colorectal tumors that develop in patients with IBD differ from those of patients without IBD. We performed whole-exome sequencing analyses to characterize the genetic landscape of these tumors. METHODS: We collected colorectal tumor and...

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Topics

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Share to Biomarkers, Tumor
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colitis, Ulcerative

Share to Colorectal Neoplasms

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Share to DNA Copy Number Variations

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Source

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Identifiers

PMID: 26764183
DOI: 10.1053/j.gastro.2015.12.036
PMCID: PMC5270616

Genes

APC
KRAS
MLH1
MSH6
NRG1
POLE
SOX9

Provenance

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