Article
Exome capture sequencing of adenoma reveals genetic alterations in multiple cellular pathways at the early stage of colorectal tumorigenesis.
PloS one - 1 Jan 2013
Zhou Donger, Yang Liu, Zheng Liangtao, Ge Weiting, Li Dan, Zhang Yong, Hu Xueda, Gao Zhibo, Xu Jinghong, Huang Yanqin, Hu Hanguang, Zhang Hang, Zhang Hao, Liu Mingming, Yang Huanming, Zheng Lei, Zheng Shu
Abstract excerpt
Most of colorectal adenocarcinomas are believed to arise from adenomas, which are premalignant lesions. Sequencing the whole exome of the adenoma will help identifying molecular biomarkers that can predict the occurrence of adenocarcinoma more precisely and help understanding the molecular pathways underlying the initial stage of colorectal tumorigenesis. We performed the exome capture sequencing of the normal...
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