Article

Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions

2022-11-16

Abstract excerpt

<h4>ABSTRACT</h4> To characterise the somatic alterations in colorectal cancer (CRC), we conducted whole-genome sequencing analysis of 2,023 tumours. We provide the most detailed high-resolution map to date of somatic mutations in CRC, and demonstrate associations with clinicopathological features, in particular location in the large bowel. We refined the mutational processes and signatures acting in colorectal t...

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Literature Corpus work: a9c34217-d16e-5982-8cdd-fe29e996fe90
DOI: 10.1101/2022.11.16.515599

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