Article
From APC to the genetics of hereditary and familial colon cancer syndromes.
Human molecular genetics - 1 Oct 2021
Olkinuora Alisa P, Peltomäki Päivi T, Aaltonen Lauri A, Rajamäki Kristiina
Abstract excerpt
Hereditary colorectal cancer (CRC) syndromes attributable to high penetrance mutations represent 9-26% of young-onset CRC cases. The clinical significance of many of these mutations is understood well enough to be used in diagnostics and as an aid in patient care. However, despite the advances made in the field, a significant proportion of familial and early-onset cases remains molecularly uncharacterized and...
Topics
- Adenomatous Polyposis Coli
- Alleles
- Animals
- Cell Transformation, Neoplastic
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Disease Progression
- Genetic Association Studies
- Genetic Linkage
- Genetic Predisposition to Disease
- Genomics