Article
Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing.
Medical oncology (Northwood, London, England) - 1 Oct 2016
Jauhri Mayank, Bhatnagar Akanksha, Gupta Satish, Shokeen Yogender, Minhas Sachin, Aggarwal Shyam
Abstract excerpt
Mutation frequencies of common genetic alterations in colorectal cancer have been in the spotlight for many years. This study highlights few rare somatic mutations, which possess the attributes of a potential CRC biomarker yet are often neglected. Next-generation sequencing was performed over 112 tumor samples to detect genetic alterations in 31 rare genes in colorectal cancer. Mutations were detected in 26/31...
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