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Article

Whole-exome sequencing identified mutational profiles of high-grade colon adenomas.

Oncotarget - 24 Jan 2017

Lee Sung Hak, Jung Seung Hyun, Kim Tae-Min, Rhee Je-Keun, Park Hyeon-Chun, Kim Min Sung, Kim Sung Soo, An Chang Hyeok, Lee Sug Hyung, Chung Yeun-Jun

Abstract excerpt

Although gene-to-gene analyses identified genetic alterations such as APC, KRAS and TP53 mutations in colon adenomas, it is largely unknown whether there are any others in them. Mutational profiling of high-grade colon adenoma (HGCA) that just precedes colon carcinoma might identify not only novel adenoma-specific genes but also critical genes for its progression to carcinoma. For this, we performed whole-exome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28179590
DOI: 10.18632/oncotarget.14172
PMCID: PMC5351654

Genes

APC
ARID2
KRAS
SMAD4
ATM
CNOT1
GNAQ
GNAS
MTOR
NRAS
RET
POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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