The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis.

doi:10.1152/ajplung.00395.2017

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Article

The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology - 1 Jul 2018

Okamoto Tsukasa, Mathai Susan K, Hennessy Corinne E, Hancock Laura A, Walts Avram D, Stefanski Adrianne L, Brown Kevin K, Lynch David A, Cosgrove Gregory P, Groshong Steve D, Cool Carlyne D, Schwarz Marvin I, Banda Nirmal K, Thurman Joshua M, Yang Ivana V, Holers V Michael, Schwartz David A

Abstract excerpt

The common gain-of-function MUC5B promoter variant ( rs35705950 ) is the strongest risk factor for the development of idiopathic pulmonary fibrosis (IPF). While the role of complement in IPF is controversial, both MUC5B and the complement system play a role in lung host defense. The aim of this study was to evaluate the relationship between complement component 3 (C3) and MUC5B in patients with IPF and in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29565179
DOI: 10.1152/ajplung.00395.2017
PMCID: PMC6087895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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