Article

Lung epithelial cell-derived C3 protects against pneumonia-induced lung injury

2022-02-05

Abstract excerpt

The complement component C3 is a fundamental plasma protein for host defense. However, recent work has demonstrated the critical importance of local C3 expression in cell survival. Here we analyzed the effects of local versus peripheral sources of C3 expression in a model of bacterial pneumonia. While mice with global C3 deficiency had severe pneumonia-induced lung injury, those deficient in liver-deficient C3 rem...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b708144-70bf-50e0-ac0e-ccf50fe532ae
DOI: 10.1101/2022.02.03.478963

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lung epithelial cell-derived C3 protects against pneumonia-induced lung injuryDOI 10.1101/2022.02.03.478963Read

Kinetics of local C3 production orchestrates neutrophil recruitment in lung injurySemantic proximity Read

Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell DeathSemantic proximity Read

hPSC-Derived Distal Lung Organoids Reveal Respiratory Airway Secretory Cells Acting as Immune Sentinels in Human Distal AirwaysSemantic proximity Read

Local, but not circulating, complement C3 governs immune checkpoint blockade efficacySemantic proximity Read

PROS1 released by human lung basal cells upon SARS-CoV-2 infection facilitates epithelial cell repair and limits inflammationSemantic proximity Read

The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target?Semantic proximity Read

The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis.Semantic proximity Read

Generation of complement C3 and expression of cell membrane complement inhibitory proteins by human bronchial epithelium cell lineSemantic proximity Read

Effects of C3aR activated mast cells in eosinophilic esophagitisSemantic proximity Read

Loss of Peripheral Tolerance in Emphysema. Phenotypes, Exacerbations, and Disease Progression.Semantic proximity Read

Series Introduction: Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repairSemantic proximity Read

Complement is primarily activated in the lung in a mouse model of severe COVID-19Semantic proximity Read