Article
The Presence of T Allele (rs35705950) of the MUC5B Gene Predicts Lower Baseline Forced Vital Capacity and Its Subsequent Decline in Patients with Hypersensitivity Pneumonitis.
International journal of molecular sciences - 28 Jun 2023
Lewandowska Katarzyna B, Szturmowicz Monika, Lechowicz Urszula, Franczuk Monika, Błasińska Katarzyna, Falis Maria, Błaszczyk Kamila, Sobiecka Małgorzata, Wyrostkiewicz Dorota, Siemion-Szcześniak Izabela, Bartosiewicz Małgorzata, Radwan-Röhrenschef Piotr, Roży Adriana, Chorostowska-Wynimko Joanna, Tomkowski Witold Z
Abstract excerpt
Hypersensitivity pneumonitis (HP) is an exposure-related interstitial lung disease with two phenotypes-fibrotic and non-fibrotic. Genetic predisposition is an important factor in the disease pathogenesis and fibrosis development. Several genes are supposed to be associated with the fibrosing cascade in the lungs. One of the best-recognized and most prevalent is the common MUC5B gene promoter region polymorphism...
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