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Article

The Possible Pathogenesis of Idiopathic Pulmonary Fibrosis consideringMUC5B

11 Jun 2019

Abstract excerpt

Background.Overexpression of the MUC5B protein is associated with idiopathic pulmonary fibrosis (IPF), but little information is available regarding the pathogenic effects and regulatory mechanisms of overexpressed MUC5B in IPF.Main Body.The overexpression of MUC5B in terminal bronchi and honeycomb cysts produces mucosal host defensive dysfunction in the distal airway which may play an important role in the...

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PMID: 31309122
DOI: 10.1155/2019/9712464

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