Article
N-Nitrosodimethylamine investigations in Muta™Mouse define point-of-departure values and demonstrate less-than-additive somatic mutant frequency accumulations.
Mutagenesis - 12 Mar 2024
Lynch Anthony M, Howe Jonathan, Hildebrand Deon, Harvey James S, Burman Mark, Harte Danielle S G, Chen Liangfu, Kmett Casey, Shi Wei, McHugh Charles F, Patel Kinnari K, Junnotula Venkat, Kenny Julia, Haworth Richard, Wills John W
Abstract excerpt
The N-nitrosamine, N-nitrosodimethylamine (NDMA), is an environmental mutagen and rodent carcinogen. Small levels of NDMA have been identified as an impurity in some commonly used drugs, resulting in several product recalls. In this study, NDMA was evaluated in an OECD TG-488 compliant Muta™Mouse gene mutation assay (28-day oral dosing across seven daily doses of 0.02-4 mg/kg/day) using an integrated design that...
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