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Impact of DNA polymerase ζ mutations on genotoxic thresholds of oxidative mutagens.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Apr 2018

Suzuki Tetsuya, Matsumoto Kyomu, Honma Masamitsu, Nohmi Takehiko

Abstract excerpt

In regulatory genetic toxicology, it is an axiom that there is no threshold for genotoxicity of chemicals, such that genotoxic chemicals may impose carcinogenic risk on humans even at very low doses. This paradigm is counterintuitive, however, because humans possess a number of self-defense mechanisms that may suppress the genotoxicity at these low doses and therefore manifest a practical threshold. DNA...

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PMID: 29555059
DOI: 10.1016/j.mrgentox.2018.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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