Article
DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure.
Proceedings of the National Academy of Sciences of the United States of America - 29 Nov 2016
Lin Ying-Chih, Owen Nichole, Minko Irina G, Lange Sabine S, Tomida Junya, Li Liang, Stone Michael P, Wood Richard D, McCullough Amanda K, Lloyd R Stephen
Abstract excerpt
Routine dietary consumption of foods that contain aflatoxins is the second leading cause of environmental carcinogenesis worldwide. Aflatoxin-driven mutagenesis is initiated through metabolic activation of aflatoxin B1 (AFB1) to its epoxide form that reacts with N7 guanine in DNA. The resulting AFB1-N7-dG adduct undergoes either spontaneous depurination or imidazole-ring opening yielding formamidopyrimidine AFB1...
Topics
- Aflatoxin B1
- Aflatoxins
- Animals
- Carcinoma, Hepatocellular
- Cell Survival
- Chromosome Aberrations
- Cytidine
- DNA Adducts
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- DNA-Directed DNA Polymerase
- Fibroblasts