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Article

DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure.

Proceedings of the National Academy of Sciences of the United States of America - 29 Nov 2016

Lin Ying-Chih, Owen Nichole, Minko Irina G, Lange Sabine S, Tomida Junya, Li Liang, Stone Michael P, Wood Richard D, McCullough Amanda K, Lloyd R Stephen

Abstract excerpt

Routine dietary consumption of foods that contain aflatoxins is the second leading cause of environmental carcinogenesis worldwide. Aflatoxin-driven mutagenesis is initiated through metabolic activation of aflatoxin B1 (AFB1) to its epoxide form that reacts with N7 guanine in DNA. The resulting AFB1-N7-dG adduct undergoes either spontaneous depurination or imidazole-ring opening yielding formamidopyrimidine AFB1...

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Identifiers

PMID: 27849610
DOI: 10.1073/pnas.1609024113
PMCID: PMC5137696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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