Article
The role of hRev7, the accessory subunit of hPolζ, in translesion synthesis past DNA damage induced by benzo[a]pyrene diol epoxide (BPDE).
BMC cell biology - 10 Dec 2010
Neal Jessica A, Fletcher Kathryn L, McCormick J Justin, Maher Veronica M
Abstract excerpt
BACKGROUND: DNA polymerase zeta (Polζ) is a specialized DNA polymerase that, unlike classical replicative polymerases, is capable of replicating past DNA lesions, i.e. of performing translesion synthesis (TLS). The catalytic subunit of hPolζ, hRev3, has been shown to play a critical role in DNA damage-induced mutagenesis in human cells, but less is known about the role of hRev7, the accessory subunit of hPolζ, in...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Cell Line
- Cell Survival
- DNA
- DNA Damage
- DNA-Directed DNA Polymerase
- Humans
- Mad2 Proteins
- Mutagens
- Mutation
- Protein Subunits
- Proteins