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Mutant cells defective in DNA repair pathways provide a sensitive high-throughput assay for genotoxicity.

DNA repair - 10 Dec 2010

Evans Terry John, Yamamoto Kimiyo N, Hirota Kouji, Takeda Shunichi

Abstract excerpt

Chemicals used industrially and commercially are required by law to be assessed for their genotoxic potential. However, all currently used assays have major limitations and despite intense effort, there is no universal agreement on which tests should be employed, or how to interpret results. We have developed a new assay system using the chicken DT40 B cell line that offers a number of significant advantages over...

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Identifiers

PMID: 21030320
DOI: 10.1016/j.dnarep.2010.09.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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