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Article

DNA polymerase zeta generates clustered mutations during bypass of endogenous DNA lesions in Saccharomyces cerevisiae.

Environmental and molecular mutagenesis - 1 Dec 2012

Stone Jana E, Lujan Scott A, Kunkel Thomas A, Kunkel Thomas A

Abstract excerpt

Multiple sequence changes that are simultaneously introduced in a single DNA transaction have a higher probability of altering gene function than do single base substitutions. DNA polymerase zeta (Pol ζ) has been shown to introduce such clustered mutations under specific selective and/or DNA dama...

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Identifiers

PMID: 22965922
DOI: 10.1002/em.21728
PMCID: PMC3678557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22965922-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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