Article
DNA polymerase zeta generates clustered mutations during bypass of endogenous DNA lesions in Saccharomyces cerevisiae.
Environmental and molecular mutagenesis - 1 Dec 2012
Stone Jana E, Lujan Scott A, Kunkel Thomas A, Kunkel Thomas A
Abstract excerpt
Multiple sequence changes that are simultaneously introduced in a single DNA transaction have a higher probability of altering gene function than do single base substitutions. DNA polymerase zeta (Pol ζ) has been shown to introduce such clustered mutations under specific selective and/or DNA damage-producing conditions. In this study, a forward mutation assay was used to determine the specificity of spontaneous...
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